To compare the difference in cumulative live birth rates between dual ovarian stimulation and two antagonist stimulations in poor ovarian responders.
Women with POR were defined with adjusted Bologna criteria, at least two of the three following criteria: advanced maternal age (40 years); 3 oocytes in previous IVF; and antral follicle count (AFC) 5 and/or anti-Mu¨llerian hormone (AMH) 1.1 ng/ml (this criterion was mandatory)
Aged from 20 to 44 years
Body mass index (BMI) from 19 to 32 kg/m2
No more than two previous IVF cycles were recruited
Amenorrhoea
Follicle stimulating hormone (FSH) 20 IU/L or AFC 1
Women with a partner with an extremely severe sperm anomaly or sperm donor use
Parallel
duostim vs. two antagonist ovarian stimulations
Procedure/SurgeryHuman menopausal gonadotropin (HMG) 300 IU/day with flexible antagonist protocol is used for ovarian stimulation, except in luteal phase stimulation of the duostim group. In the duostim group, all of the embryos are frozen. Fresh transfers are performed in the control group, frozen embryo transfers are performed in both control and duostim groups.
Cumulative live birth rate
Live birth is defined as the delivery of any alive infant after 22 weeks of gestation after our interventions, and cumulative live birth rate is calculated by the total number of women randomized to the specific group.
Time to live birth (TTLB)
The TTLB was measured as the time from ovarian stimulation to a live birth.
Total amount of Gn used during ovarian stimulation
Total amount of Gn used during ovarian stimulation
Number of retrieved oocytes
Number of retrieved oocytes after ovarian stimulation.
Clinical pregnancy rate
Twenty days after conception, transvaginal ultrasonography will be performed. Clinical pregnancy will be diagnosed with detection of an intrauterine gestational sac.
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