Cytokine Expression in Psoriasis Patients With and Without Joint Involvement
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-100
SponsorPoitiers University Hospital
About this trial
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age over 18 years old
Signed informed consent
5 year old psoriasis at least
At least one skin lesion over 2 cm
Disqualifiers
Joint damage according to CASPAR criteria
Echography activity in favor of chronic inflammatory rheumatism
Without social protection rights
People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.
Trial design
Design model
Parallel
Treatments tested in this trial
Blood sample collection
Other interventionBlood sample collection
Skin sample collection
Other interventionSkin sample collection
Treatment groups
40 Participants
are divided into 3 treatment groupsGroup A: PsoriasisExperimental treatment 2 interventions
Group B: Psoriatic arthritisExperimental treatment 2 interventions
Group C: ControlsActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Comparison of cytokine levels in sera, after culture of PBMC stimulated with LPS or CD3/CD28 agonist antibodies between the three groups
Comparison of cytokine levels in sera, after culture of PBMC stimulated with LPS or CD3/CD28 agonist antibodies between the three groups
Time frame
At inclusionSecondary outcomes
1
Comparison of cytokine levels in skin biopsies between Psoriatic Arthritis and Cutaneous Psoriasis patients
Comparison of cytokine levels in skin biopsies between Psoriatic Arthritis and Cutaneous Psoriasis patients
Time frame
At inclusion2
Correlation of cytokine levels with rheumatologic disease activity, or dermatologic disease activity
Correlation of cytokine levels with rheumatologic disease activity, or dermatologic disease activity
Time frame
At inclusionSponsors and contacts
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Source ClinicalTrials.gov