DCE-MRI Based on 4D Free Breathing for Predicting Preoperative Neoadjuvant Chemoradiotherapy for Esophageal Cancer

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorYunnan Cancer Hospital

About this trial

To prospectively collect medical images and clinical data related to esophageal cancer using 4D Free Breathing DCE-MRI technology, to evaluate the image quality in the diagnosis of esophageal cancer, and to predict the efficacy of preoperative neoadjuvant chemoradiotherapy for esophageal cancer.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Be 18 years of age and older;

First diagnosis of esophageal squamous cell carcinoma confirmed by histopathological biopsy;

The clinical stage is cT1b~cT2N+; or the clinical stage is cT3~cT4 any N, (thoracic esophageal cancer, esophagogastric junction cancer);

There are no contraindications to MRI examination

Disqualifiers

Have other primary tumors;

The image quality does not meet the diagnostic criteria;

Those who do not cooperate with the inspection;

Patients who have received prior chemoradiotherapy

Trial design

Design model

Single group

Treatments tested in this trial

  • The application value of MRI 4D Free Breathing DCE-MRI in the treatment of esophageal cancer

    Diagnostic test

    Chest MRI scan outside of standard treatment options

Treatment groups

135 Participants
are divided into 1 treatment group
Group A: Application of DCE-MRI based on 4D Free Breathing in predicting the efficacy of preoperative neoadjuExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Tumor response assessment

This study aims to assess tumor treatment response using pathology gold standard pCR . pCR refers to the state in which the pathological tumor completely disappears after systemic therapy, such as chemotherapy, targeted therapy, or endocrine therapy.

Time frame
Surgery was performed within one month after neoadjuvant therapy, and the pathological pCR of the pathological results obtained from the surgery was used as the gold standard in this study to evaluate tumor treatment response

Secondary outcomes

Other outcomes

Sponsors and contacts

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