Deceased Uterine Transplant in Absolute Uterine Infertility (AUIF)
ConditionInfertility of Uterine Origin
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorBrigham and Women's Hospital
About this trial
Our study will explore the feasibility of initiating a deceased donor uterine transplant program in addition to the existing living donor IRB at BWH.
Using the template established by teams around the world, we will identify emotionally and socially stable females of reproductive age with intact ovaries who are unable to gestate a child due to congenital or acquired uterine factor infertility. After careful screening, participants will undergo egg harvest, in vitro fertilization, and embryo cryopreservation using standard methods. Women who successfully complete the fertilization of at least six euploid embryos will be eligible to be placed on the waitlist for a deceased donor uterus transplant. After a successful transplant and a period of observation to ensure normal menstrual cycle and graft viability (anticipate six months), embryo implantation will be undertaken.
Following an embryo transfer, gestation will be carefully monitored by our high-risk pregnancy specialists. Medical research interventions include the surgical implantation of a uterus utilizing techniques by teams that have applied this approach successfully, close post-transplant follow up including immunosuppression therapy tailored to established standards during pregnancy minimizing fetal risks, and careful management of pregnancy. After childbearing is complete (at most two gestations), the donor uterus will be removed either during Cesarean or during an elective procedure. In addition, open ended interviews and surveys will be conducted to elicit ethical and psychosocial concerns arising from the experience of subjects and their families, health care providers, and the wider community. The investigator's intent is to monitor outcomes for transplant recipients as well as the live born infants for 30 days after removal of the transplanted uterus.
It is estimated that the time from screening to a potential live birth will be a minimum of 22 months, but likely between 24 - 36 months depending on organ availability.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Evidence of AUFI diagnosed by BWH gynecologist
Ability to produce at least 6 euploid embryos for cryopreservation
BMI ≤ 30
GFR 60 or greater in any patient including those with a single kidney
Disqualifiers
Active smoking, alcohol use or use of illicit drugs
Inability to follow a strict medication dosing schedule post-transplant and adhere to required follow-up appointments.
Any co-morbidities which would increase surgical risk, risk of pregnancy or the risk of taking anti-rejection medications as determined by the Maternal Fetal Specialist and Transplant Surgeon.
Active infection: HIV, Hepatitis B, Hepatitis C
Trial design
Design model
Single group
Treatments tested in this trial
Uterine Transplant from Deceased Donor
Procedure/SurgeryThe recipient will be started on anti-rejection medications (as is routine for transplant recipients) prior to the OR. Standard of care anesthesia and line placement will take place. The recipient will be appropriately identified as an organ recipient and the donor organ identified per required transplant protocols already in place. The recipient team will then connect the vasculature and appropriate supporting structures for the uterus transplant. Once the organ has been re-perfused, the remainder of the operation will take place and the patient will be moved to the Intensive Care Unit and later to the transplant patient floor for standard monitoring.
Treatment groups
250 Participants
are divided into 1 treatment groupGroup A: Deceased Donor Uterus TransplantExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Number of Live Births Following Uterus Transplant
To provide motherhood options for women with AUIF as an alternative to surrogacy or adoption, via gestating and giving birth via Cesarean section to a live infant.
Time frame
Within 5 years of transplant2
Number of Surgically Successful Uterus Transplants
To achieve surgically successful uterus transplants.
Time frame
Within 3 months of transplantSecondary outcomes
1
Financial impact of deceased donor uterus transplantation
To analyze the overall impact of deceased donor uterus transplantation costs relative to established alternative procedures such as adoption and surrogacy.
Time frame
Through Study completion, up to 5 years post transplant2
Quality of life impact of deceased donor uterus transplantation
To analyze the overall impact of deceased donor uterus transplantation including changes in quality of life, relative to other established alternative procedures such as adoption and surrogacy.
Time frame
Through study completion, up to 5 years post transplantSponsors and contacts
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Source ClinicalTrials.gov