Dental Management of Patients With HIV in Pays de la Loire
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNantes University Hospital
About this trial
Dental care for people living with HIV has evolved with the widespread use of antiretroviral therapy, which has improved life expectancy and disease control. However, uncertainty remains about whether specific adaptations are still needed during dental procedures due to potential biological abnormalities that may increase infectious or bleeding risks.
This study aims to evaluate the proportion of patients living with HIV in the Pays de la Loire region who may require adapted dental management based on biological parameters such as immune status, hematological values, and comorbidities.
A retrospective descriptive study will be conducted using anonymized data from 5,603 patients followed in the COREVIH Pays de la Loire database. The results are expected to provide objective data to better inform dental practice and reduce unnecessary precautions or stigmatization in the management of patients living with HIV.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients aged ≥18 years
Confirmed diagnosis of HIV infection
Followed at participating hospital centers
Available clinical and biological data relevant to dental care management (CD4 count, viral load, blood count)
Disqualifiers
Patients with missing key biological data required for analysis
Patients not followed in participating centers
Patients with incomplete medical records preventing assessment of outcomes
Trial population
Adult patients living with HIV followed in hospital-based infectious diseases departments in France, identified retrospectively from routine clinical records and biological databases.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
HIV infection status and clinical characteristics
Other interventionObservational assessment of clinical, biological, and comorbidity data in patients living with HIV, including CD4 count, viral load, hematological parameters, and associated conditions, collected from routine care without any intervention.
Treatment groups
5,603 Participants
are divided into 1 treatment groupGroup A: Patients With HIV1 intervention
Trial outcomes
Primary outcomes
1
Proportion of Patients Requiring Adapted Dental Management
Percentage of patients living with HIV presenting at least one biological abnormality associated with increased risk of infectious or hemorrhagic complications during invasive dental procedures, including low CD4 count, neutropenia, thrombocytopenia, or anemia, based on routinely collected clinical data.
Time frame
At time of data extraction (retrospective baseline)Secondary outcomes
1
CD4 Cell Count Distribution
CD4 lymphocyte count (cells/mm³) distribution among patients, used to assess immune status. Lower values indicate greater immunosuppression.
Time frame
At time of data extraction (retrospective baseline)2
Neutrophil Count Distribution
Neutrophil count (cells/mm³) measured from routine blood tests. Lower values indicate increased risk of infection.
Time frame
At time of data extraction (retrospective baseline)3
Platelet Count Distribution
Platelet count (×10⁹/L) measured from routine blood tests. Lower values indicate increased bleeding risk.
Time frame
At time of data extraction (retrospective baseline)4
Hemoglobin Level Distribution
Hemoglobin level (g/dL) measured from routine blood tests. Lower values indicate anemia.
Time frame
At time of data extraction (retrospective baseline)Sponsors and contacts
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Source ClinicalTrials.gov