Depressive Symptoms, Cognitive Impairment, and Outcomes in Hospitalized Chronic Heart Failure Patients

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-85
SponsorLithuanian University of Health Sciences

About this trial

The goal of this observational study is to learn about the prevalence of depressive symptoms and cognitive impairment and their association with worse outcomes in a cohort of hospitalized patients between the ages of 18 ang 85 years with chronic heart failure. The main question it aims to answer is:

• Does the presence of depressive symptoms and cognitive impairment lead to worse outcomes in a cohort of hospitalized patients with chronic heart failure? Participants who are hospitalized due to exacerbation of chronic heart failure will answer survey questions to assess their cognitive function and depressive symptoms.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

patient hospitalized primarily for CHF exacerbation;

clinically stable, able to provide informed consent;

do not have severe cognitive impairment that would preclude valid questionnaire administration.

Disqualifiers

hospitalization for acute heart failure;

total length of hospital stay <96 hours;

absence of transthoracic echocardiography (TTE) within the last 12 months and no TTE planned;

severe visual impairment preventing completion of the visual part of the Montreal Cognitive Assessment;

Trial population

Patients hospitalized to the Department of Cardiology and the Internal Medicine Department's Cardiology Profile at the Lithuanian University of Health Sciences Kaunas Hospital, Kaunas, Lithuania

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

300 Participants
are grouped into 1 trial group
Group A: CHF Group

Trial outcomes

Primary outcomes

1

In-hospital all-cause mortality

Lethal all-cause outcome

Time frame
From enrollment to the end of treatment up to 30 days
2

In-hospital MACE

In-hospital Major Adverse Cardiovascular Event (including myocardial infarction, stroke, cardiovascular death, and need for revascularization \[like repeat PCI or bypass surgery\])

Time frame
From enrollment to the end of treatment up to 30 days
3

Number of Participants with chronic heart failure-related rehospitalization

Subsequent hospitalization due to chronic heart failure exacerbation (decompensation) within 12 months after the index admission to the hospital (enrollment to the study)

Time frame
12 months post discharge from the hospital

Secondary outcomes

Other outcomes

Sponsors and contacts

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