Detection of Small Fiber Neuropathy Using Skin Properties
ConditionSmall Fiber Neuropathy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBrigham and Women's Hospital
About this trial
Small fiber neuropathy affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, too much or too little sweating. The detection of nerve damage is complicated and not widely available; it requires either skin biopsy or specialized equipment and training. This project utilizes the mathematical processing of skin pictures for the purpose to extract the statistical features related to loss of small fibers. This approach can improve the availability of diagnosis of small fiber neuropathy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients with age 18 year or older
Patients that sign the informed consent form to participate in this study
Patients completed the autonomic testing with skin biopsies
Disqualifiers
Patients with significant hairs at the legs that will cover the skin
Any dermatological disorder that can affect the skin composition
The use of skin lotion
Trial population
Patients with small fiber neuropathy
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Image processing of skin
Other interventionImage processing will be used to extract skin features that correlate with loss of small skin fibers.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Diagnostic accuracy of image processing
The diagnostic accuracy of image processing will be evaluated by using the skin biopsy as a reference.
Time frame
2 yearsSponsors and contacts
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Source ClinicalTrials.gov