Detection of Unsuspected Small Airways Obstruction in Cystic Fibrosis
ConditionCystic Fibrosis in Children
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age5-40
SponsorGelb, Arthur F., M.D.
About this trial
Goal is to physiologically detect unsuspected small airways obstruction in children and adults with treated heterozygous and homozygous cystic fibrosis. Unsuspected refers to normal routine pre bronchodilator spirometry including normal FEV1(L), FVC (L). and FEV1/FVC%. This is a retrospective study.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
Review pulmonary function and radiologic studies in retrospective records of heterozygote or homozygote patients with cystic fibrosis
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
spirometry
Diagnostic testmeasure spirometry and lung CT
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Detection of Unsuspected Small Airway Obstruction in Cystic Fibrosis
Retrospective analysis of pre bronchodilator spirometry, and lung CT study to detect abnormal FEF75% in the presence of normal spirometry and FEF25-75. Detect isolated abnormal pre bronchodilator spirometry at 75%FVC
Time frame
5 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Gelb, Arthur F., M.D.
Lead sponsor
Miller Children's & Women's Hospital Long Beach
Collaborator
Stony Brook University
Collaborator
The Hospital for Sick Children
Collaborator
Source ClinicalTrials.gov