Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation

ConditionAllogeneic Hematopoietic Stem Cell Transplantation

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorCentral Hospital, Nancy, France

About this trial

The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

patient of the Nancy CHRU, for whom a CSH allograft is planned. or

hematopoietic stem cell donors received at Nancy's CHRU for the duration of the research

Disqualifiers

Positive HIV

active hepatitis B or C infection

Trial design

Design model

Parallel

Treatments tested in this trial

Blood Sample
Biological/Vaccine
Additional blood sample before graft, D0, D7, D15, D21, D30, D60, D90, D180, Y1, Y2
Bone marrow aspiration
Biological/Vaccine
Additional bone marrow aspiration before graft, D30, D90, Y1
Blood sample
Biological/Vaccine
Before donation
Allogeneic hematopoietic stem cell sample
Biological/Vaccine
Allogeneic hematopoietic stem cell sample

Treatment groups

700 Participants

are divided into 2 treatment groups

Group A: RecipientExperimental treatment 2 interventions

Group B: DonorExperimental treatment 2 interventions