Determination of Risk Factors of Shoulder Pathologies in Parkinson Disease

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50+
SponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

About this trial

Parkinson's disease was first described in history in 1817 by James Parkinson in his monograph "An essay on swinging palsy", and today it is the 2nd most common neurodegenerative disease after Alzheimer's, affecting approximately 6.1 million people. Its main histopathological feature is the decrease in dopaminergic secretion in the basal ganglia and there are three cardinal findings: Bradykinesia, Tremor, Rigidity. Although joint and skeletal deformities are seen in approximately 70% of Parkinson's patients, they are not adequately evaluated and cause significant functional disability and chronic pain, independent of motor symptoms.Musculoskeletal pathologies seen in Parkinson's patients can be classified as: musculoskeletal pain, articular problems, postural problems and bone mineralization defects. The shoulder girdle is a joint with complex and delicate function, consisting of four joints (glenohumeral, sternoclavicular, acromioclavicular and scapulothoracic), supporting muscles and periarticular ligaments, which seriously affects the patient's quality of daily life and function. Although magnetic resonance imaging (MRI) is the best imaging tool in the diagnosis of musculoskeletal system pathologies, it is quite sensitive to artifact-forming motion. Ultrasound (US) imaging is widely used in the evaluation of rotator cuff muscles, biceps muscle and glenohumeral joint pathologies and has many advantages over MRI, such as providing fast, cheap and dynamic imaging. Although many studies have proven that shoulder girdle musculoskeletal pathologies such as bicipital tendinitis, m.supraspinatus tendinosis, subacromial/subdeltoid bursitis, subacromial impingement syndrome, and adhesive capsulitis are seen more frequently in Parkinson's patients by ultrasonographic imaging, these shoulder girdle pathologies seen in Parkinson's patients are more common. The risk factors for pathologies have not been defined. In this study, we aimed to determine the ultrasonographic findings and risk factors of shoulder pathologies in Parkinson's patients and to investigate the effects of shoulder pathologies on quality of daily life, physical activity, falls and balance.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Being diagnosed with Parkinson's according to the Movement Disorders Society diagnostic criteria

Being over 50 years old

Being in the Hoehn & Yahr stage I-IV range

Identification of pain in at least one shoulder (VAS>3)

Disqualifiers

Scoring less than 24 points in the Mini Mental Test

Having had a myocardial infarction

Having had a cerebrovascular accident

Having a rheumatological disease

Trial population

The study will be carried out cross-sectionally and in a single center, with patients diagnosed with Parkinson's disease who apply to the Physical Medicine and Rehabilitation Polyclinic of the University of Health Sciences Sultan 2.Abdülhamid Han Training and Research Hospital, and healthy volunteers who describe pain in any shoulder and who do not describe pain in any shoulder. The number of samples was calculated with G-power.Total of 160 patients and 320 shoulders were calculated.

Trial design

Design model

Case-crossover

Time perspective

Cross-sectional

Treatments tested in this trial

  • ULTRASOUND

    Diagnostic test

    Measurements will be made in musculoskeletal system ultrasonography by an international Medicine and Rehabilitation assistant physician using images obtained with the Sonosite M-Turbo device using the ImageJ program. During the measurements, the patient and the patient will be face to face and the device will be placed postero-laterally. Five standard window spacings will be used for the shoulder attachment. These are: anterior transverse, anterior longitudinal, lateral longitudinal, lateral transverse, posterior transverse.

Treatment groups

160 Participants
are divided into 4 treatment groups
Group A: Group 11 intervention
Group B: Group 21 intervention
Group C: Group 31 intervention
Group D: Group 41 intervention

Trial outcomes

Primary outcomes

1

USG FINDINGS

Measurements will be made by a Physical Medicine and Rehabilitation assistant physician experienced in musculoskeletal system ultrasonography, using the images obtained with the Sonosite M-Turbo device using the ImageJ program. During the measurements, the device will be positioned on the postero-lateral side of the patient while the patient and the practitioner are face to face. Five standard viewing windows will be used for the shoulder joint. These are: anterior transverse, anterior longitudinal, lateral longitudinal, lateral transverse, posterior transverse.

Time frame
ONE MONTH

Secondary outcomes

Other outcomes

Sponsors and contacts

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