About this trial
After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, aged 18-35, who had ACL surgery. They'll be split into two groups: one receiving real brain stimulation and another getting a placebo, both during thigh-strengthening exercises. Over six sessions, the investigators measure thigh muscle strength, speed, and steadiness, plus two brain signal measures, using special equipment. The investigators will also check if stronger brain signals lead to better muscle performance, especially in women. Our goal is to show that this new method strengthens thigh muscles better than standard rehab, helping women recover better after surgery. If successful, this could improve physical therapy for women recovering from ACL surgery, making daily activities and return to sport easier.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
multiple ligament reconstruction
osteochondral procedures
any previous lower extremity surgery
previous ACL injury
Trial design
Parallel
Treatments tested in this trial
active transcranial direct current stimulation (tDCS)
Device20 minutes of anodal tDCS over the primary motor cortex contralateral to the participants surgical limb during a quadriceps torque matching task
sham transcranial direct current stimulation (tDCS)
DeviceParticipants receive sham tDCS in which the device only delivers current during the first and last 30 seconds while participants perform a quadriceps torque matching task
Treatment groups
Trial outcomes
Primary outcomes
Peak quadriceps muscle torque
Peak torque during a 5 second maximal voluntary isometric contraction
Corticospinal excitability (Slope)
Slope of a TMS induced stimulus-response curve
Secondary outcomes
Rate of Torque Development (RTD)
RTD of a maximal voluntary isometric contraction from onset to 100ms (RTD100) and from 100 to 200ms (RTD200) will be used.
Corticospinal excitability (Active Motor Threshold)
The lowest stimulator intensity needed to produce consistent MEPs \>/= 100 microvolts while the participant maintains an isometric contraction at 5% of their MVIC
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Arcadia University
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator