About this trial
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.
Eligibility criteria
Qualifiers
Age 18-35 years
A first episode of a psychotic illness that began within the past three years
Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
Taking 2nd generation antipsychotic medications
Disqualifiers
No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis)
No evidence of moderate or severe alcohol or substance use disorder in the past 3 months
No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury
For females: no current pregnancy
Trial design
Treatments tested in this trial
- Motivational Interviewing
- Nutrition Didactic Training
Treatment groups
Sponsors and collaborators
University of Alabama at Birmingham
Lead sponsor
University of California, Los Angeles
Collaborator
National Institute of Mental Health (NIMH)
Collaborator