Determining the Role of Social Reward Learning in Social Anhedonia
ConditionPsychosis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorUniversity of Alabama at Birmingham
About this trial
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18-35 years
A first episode of a psychotic illness that began within the past three years
Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
Taking 2nd generation antipsychotic medications
Disqualifiers
No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis)
No evidence of moderate or severe alcohol or substance use disorder in the past 3 months
No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury
For females: no current pregnancy
Trial design
Design model
Parallel
Treatments tested in this trial
Motivational Interviewing
BehavioralThree motivational interviewing sessions will target sensitivity to social reward, including subjective evaluation of social interaction, socially rewarding stimuli, and events (e.g., interactions with others, feedback from others).
Nutrition Didactic Training
BehavioralThe Nutrition didactic training will ask participants to discuss pros and cons of healthy eating habits and how to improve their current eating habits.
Treatment groups
152 Participants
are divided into 2 treatment groupsGroup A: Motivational Interview InterventionExperimental treatment 1 intervention
Group B: Active Control InterventionActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Response Bias
Response bias is defined as the likelihood of making one response, such as the frequently rewarded stimulus, more than the other response during the perceptual social reward learning task
Time frame
3 weeks2
the number of optimal response
The number of optimal response is defined as the number of responses choosing a stimuli with optimal outcomes (e.g., choosing a good over a neutral machine or choosing a neutral over a bad machine) during the inductive social reward learning task.
Time frame
3 weeks3
fMRI activation levels
fMRI activation is defined as beta weights from general linear model from key regions of interests including the ventromedial prefrontal cortex, dorsal anterior cingulate cortex and ventral striatum during the perceptual social reward learning task and the inductive social reward learning task.
Time frame
3 weeksSponsors and contacts
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University of Alabama at Birmingham
Lead sponsor
University of California, Los Angeles
Collaborator
National Institute of Mental Health (NIMH)
Collaborator
Source ClinicalTrials.gov