The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns
Family history of SSD (defined as first-degree (e.g., a parent or a sibling), second-degree (e.g., an uncle or a grandparent), or other combinations of biological relatives in the family have or likely have a diagnosis of SSD or other closely related severe mental illnesses equivalent to at least 25% of genetic sharing) per medical record review and/or parent/legal guardian report and confirmed by a structured interview
screening positive for two or more risk factors targeted by the intervention
Participants and parent(s)/legal guardian(s) agree to participate
psychiatrically stable and have no major changes in antidepressant, stimulant, or antipsychotic medication in the past 4 weeks.
Current or past history of psychotic disorders or clinical high risk for psychosis (CHR-p) per study interview
Current or past antipsychotic medication use to specifically treat a psychotic disorder
major medical and neurological conditions
moderate to severe intellectual disabilities or mild intellectual disabilities but expected to have difficulty completing the study assessments;
The University of Texas Health Science Center, Houston
Lead sponsor
National Institutes of Health (NIH)
Collaborator