Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age2-18
SponsorYun Liu,PhD

About this trial

Using the knowledge graph and big model technology of combining Chinese and Western medicine we construct a popularization and prevention system for childhood encephalopathy an assisted decision-making system for childhood encephalopathy and a follow-up tracking question and answer system for childhood encephalopathy patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

1. meet diagnostic criteria for CP ID TD ADHD ASD; 2. gender is not limited;

Disqualifiers

1. CP ID TD ASD due to chorea hepatomegaly hearing abnormality and pharmacogenetic factors;

2. Children with other major mental illnesses (e.g. schizophrenia) or organic diseases (e.g. congenital heart disease);

Trial population

Childhood encephalopathy

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

  • No intervention

    Other intervention

    Pediatric Encephalopathy Science and Prevention Decision Aid Follow-Up Q\&A

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Childhood Autism Rating Scale

The total score ranges from 15 to 60, with the higher the score the worse the symptoms are

Time frame
4 mouths
2

meridian and acupointological features

After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

Time frame
4 mouths
3

Yale Global Tic Severity Scale

It has a score range of 0-100, with higher scores representing more severe symptoms.

Time frame
4 mouths
4

Gross Motor Function Assessment Scale (GMFM)-88

GMFM-88 scores range from 0-264, with higher scores being better.

Time frame
4 mouths

Secondary outcomes

1

Saliva

Destruction after use. Metabolomics after sample collection.

Time frame
4 mouths
2

blood

Destruction after use. Metabolomics after sample collection.

Time frame
4 mouths
3

Urine

Destruction after use. Metabolomics after sample collection.

Time frame
4 mouths
4

Faeces

Destruction after use. Metabolomics after sample collection.

Time frame
4 mouths

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Yun Liu,PhD

Lead sponsor

Affiliated Hospital of Nanjing University of Chinese Medicine

Sponsor institution