The characteristics of the intestinal microbiota in high-risk colorectal polyp recurrence and their relationship with disease pathogenesis have not yet been fully elucidated. This study aims to analyze the microbial community characteristics in the intestinal mucosal tissue of patients after polypectomy with recurrence of colorectal polyps. Additionally, this research holds significant importance for understanding the etiology of adenoma recurrence and develop a microbiota and metabolite-based predicting tool.
patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma
patient with severe physical diseases that prevented them from adhering to the examination requirements,
patient with coagulopathy or other contraindications for biopsy or polypectomy,
patient with previous surgical procedures on the gastrointestinal tract,
presence of colorectal cancer or other malignant tumor at baseline
patients with high-risk colorectal polyps
Cohort
Prospective
Not listed
The characteristics of the intestinal microbiota in patients with high-risk colorectal polyp recurrence
Analyze the characteristics of the microbiota within the intestinal mucosal tissue of patients with high-risk colorectal polyp recurrence or without recurrence.
Development and validation of Microbiota and metabolite-based model predicting recurrence of high-risk colorectal polyps after polypectomy
Select the recurrence and non-recurrence of polyps during the follow-up period , and develop and validate the recurrence prediction model according to the differences in intestinal mucosal flora and host gene expression levels.
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