This study is being done to help researchers learn more about and successfully diagnose cancer using blood samples and tissue samples from surgeries in patients with suspicious thyroid nodules or thyroid cancer. Diagnosing cancer in this way, as opposed to biopsies, may be less invasive to the patient. Analyzing blood and tissues samples may also help researchers to differentiate non-cancerous tumors from thyroid cancer and detect high-risk mutations to guide treatment.
Aged 18 and older
Consented for thyroid surgery for thyroid cancer or indeterminate thyroid nodule
Patients with concurrent malignancy
Patients in endocrine surgery clinic sites across University of California, Los Angeles (UCLA) who have undergone thyroid fine needle aspiration biopsy.
Cohort
Prospective
Biospecimen Collection
Procedure/SurgeryUndergo collection of blood and tissue samples
Electronic Health Record Review
Other interventionMedical charts are reviewed
Sensitivity of molecular profile of thyroid-derived extracellular vesicles
Specificity of molecular profile of thyroid-derived extracellular vesicles
Negative predictive value of molecular profile of thyroid-derived extracellular vesicles
Positive predictive value of molecular profile of thyroid-derived extracellular vesicles
Quantity of thyroid-derived extracellular vesicles captured in patients with localized, regional, and distant disease versus benign thyroid adenomas
Quantity of thyroid-derived extracellular vesicles captured in patients with excellent, indeterminate, biochemically incomplete, and structural incomplete responses to initial therapy
Combination of ribonucleic acid/deoxyribonucleic acid-based tests that can be perf thyroid-derived extracellular vesicles
Click on the lead sponsor to view all of their trials.
