Background:
\- Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new treatments for psychiatric illnesses. Researchers are interested in improving current MRI and MRS techniques, as well as developing new MRI and MRS techniques to view and measure brain chemicals and brain activity.
Objectives:
\- To implement, develop, and optimize brain chemistry imaging techniques using magnetic resonance imaging and magnetic resonance spectroscopy.
Eligibility:
\- Healthy individuals between 18 and 65 years of age.
Design:
* This study will involve a screening visit and a scanning visit at the National Institutes of Health Clinical Center. * Participants will be screened with a full medical and physical examination, blood and urine tests, and neurological testing. * During the second visit, participants will have an MRI scan of the brain. (Participants who have received an MRI within the past year will not need to have a second one; the images of the previous scan will be used for this study.) All participants will then have an MRS scan using the same scanning equipment.
18-65 years of age
able to give written informed consent
healthy based on medical history and physical exam
enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
Any current Axis 1 diagnosis
Clinically significant laboratory abnormalities
Positive HIV test
Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
Single group
NSR MAGNETOM 7T
Other interventionThe 7 Tesla scanner is a magnet system used to acquire magnetic resonance imaging and spectroscopy
1Tx x 32Rx Head Coil
Other interventionUsed to perform proton imaging and spectroscopy in the human heads.
The primary outcome is the quality of the MR spectroscopy which includes spectrum signal-to-noise (SNR) ratio, spectral lineshape, linewidth, and resolution.
to obtain more accurate and reliable MRS data from the human brain and muscle
The secondary outcome is the performance improvements of the scanner hardware, software and methodology.
to obtain more accurate and reliable MRS data from the human brain and muscle
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