Development of Organoids From Primary Colorectal Tumors and Synchronous Liver Metastases
ConditionColo-rectal Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRegina Elena Cancer Institute
About this trial
Pilot feasibility study for the development of organoids from primary colorectal tumors and synchronous liver metastases, to prepare organoids from primary colorectal tumors and synchronous liver metastases. The organoids will allow us to study the function of genes targeted by the activity of the NF-Y/p53 complex.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients > 18 years
Histological and cytological diagnosis of colorectal cancer neoplasia that has developed a liver metastasis
Patients who are candidates for surgery for colorectal cancer with liver metastasis
Signing of the relevant informed consent form.
Disqualifiers
All exclusion criteria adopted in surgical protocols will be applied to the study
Trial population
Patients with colorectal cancer and synchronous liver metastases who will undergo liver resection surgery
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Descriptive analyses
Given the pilot nature of the study, we will only perform descriptive analyses, overexpression or silencing experiments of target genes of the NF-Y/p53 complex activity. These experiments will indicate the impact on the viability of the organoid of target genes of the NF-Y/p53 complex activity. All the variables of interest will be summarized through absolute frequencies and percentages, if categorical or through medians and relative range, if continuous.
Time frame
36 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov