The goal of this clinical trial is to learn the effect of Dexamethasone and Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy
What medical problems do participants have when taking Dexamethasone and Dexmedetomidine? Researchers will compare Dexamethasone and Dexmedetomidine and Their Combination to a placebo (a look-alike substance that contains no drug) to see the effect on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy Participants will receive Dexamethasone 8 mg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Participants will receive Dexmedetomidine 0.5 mcg /kg IV + Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Participants will receive Dexamethasone 8 mg IV + Dexmedetomidine 0.5 mcg/kg IV+ Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia.
Participants will receive Saline IV (total volume 10 ml) over 10 minutes administered after induction of anesthesia
. Age 18-65 years.
American Society of Anesthesiologists (ASA) physical status I or II.
Scheduled for elective laparoscopic cholecystectomy surgery under general anesthesia.
Ability to provide written informed consent
Known allergy or contraindication to any study drug (dexamethasone, dexmedetomidine, or placebo).
Pre-existing gastrointestinal motility disorders (e.g., gastroparesis, inflammatory bowel disease).
Chronic use of opioids, steroids, or antiemetics.
History of severe cardiac disease (e.g., high-grade AV block, severe bradycardia).