Dexamethasone Versus Mg Added to Bupivacaine Used in ESPB for Perioperative Pain Control in Patients Undergoing Unilateral Nephrectomy

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorNational Cancer Institute, Egypt

About this trial

Aim of the study:

The current study aims to compare the effect of adding dexamethasone versus magnesium sulfate to bupivacaine in ultrasound-guided erector spinae plane block on the severity of postoperative pain.

Primary Objectives:

\- To compare the effect of ESPB without additives to the effect of adding dexamethasone and to the impact of adding magnesium sulfate in the form of post-operative morphine consumption

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult (18 - 65)

Patients undergoing unilateral nephrectomy

ASA II / III

Disqualifiers

Patient refusal

Age less than 18 years

Allergy to any of the studied medications

Mid line incision

Trial design

Design model

Parallel

Treatments tested in this trial

  • ultrasound guided Erector Spinae Plane Block using 27ml bupivacaine 0.25%

    Procedure/Surgery

    ESP block will be performed U/S at the level of T 10 paraspinal level. The ultrasound transducer should be placed in the midline of the back at the desired level. The probe should then slowly be moved laterally until the transverse process is visible. The transverse process requires differentiation from the rib at that level. Erector spinae muscle should be identified superficial to the transverse process. The needle inserted superior to the ultrasound probe in the cephalad to caudal direction. Once the needle tip is below the erector spinae muscle. This separation from the transverse process confirms the proper needlemposition. The local anesthetic should then be injected in 5 ml increments. The block will be performed preoperatively.

Treatment groups

78 Participants
are divided into 3 treatment groups
Group A: Normal salineActive comparator 1 intervention
Group B: magnesium sulphate 10%Active comparator 1 intervention
Group C: dexamethasoneActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

postoperative opioid consumption

total postoperative rescue analgesia be by Morphine

Time frame
24 hours post-operatively

Secondary outcomes

1

time of first rescue analgesia

Ketorolac 30 mg I.V infusion if VAS is between 3 to 6, and Morphine 3 mg I.V if VAS equals or greater than 6

Time frame
during 1st 24 postoperatively.
2

Intraoperative opioid consumption

total Intraoperative rescue analgesia will be done by giving fentanyl at dose of 1 mic/Kg

Time frame
intraoperative
3

visual analogue scale 30 hours post-operatively at rest

visual analogue scale from 0 to 10 as 0 no pain and 10 worst pain

Time frame
24 hours post-operatively at rest

Other outcomes

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