Dexmedetomidine as an Adjuvant to Bupivacaine for Ultrasound-Guided External Oblique Intercostal Block

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorAssiut University

About this trial

Effect of Adding Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block in UpperAbdominal Cancer Surgery.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged 18-70 years scheduled for elective upper abdominal cancer surgery (e.g., gastrectomy, hepatectomy, pancreatectomy).

American Society of Anesthesiologists (ASA) physical status I-III.

Body mass index (BMI) between 18-35 kg/m².

Disqualifiers

Patient refusal.

Allergy to local anesthetics or dexmedetomidine.

Coagulopathy (INR >1.5, platelet count <100,000/mm³).

Infection at the injection site.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Dexmedetomidine

    Drug

    Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block

Treatment groups

54 Participants
are divided into 2 treatment groups
Group A: Dexmedetomidine + BupivacaineExperimental treatment 1 intervention
Group B: BupivicaineActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Total Postoperative Opioid Consumption (mg of morphine equivalents)

To evaluate the effect of adding dexmedetomidine to bupivacaine on total opioid consumption within the first 24 hours after upper abdominal cancer surgery.

Time frame
24 hours postoperative.

Secondary outcomes

1

Postoperative Pain Intensity Using the Visual Analog Scale (VAS 0-10)

Pain scores will be assessed at rest and during movement using the Visual Analog Scale (0 = no pain, 10 = worst pain). Higher scores indicate worse pain.

Time frame
2, 4, 6, 12, 18, and 24 hours postoperative.
2

Time to First Request for Rescue Analgesia.

Time from block performance until first request for analgesia.

Time frame
24 hour postoperative
3

Number of Participants with Adverse Effects

Incidence of nausea, vomiting, hypotension, and bradycardia.

Time frame
first 2 hours postoperative.
4

patient satisfaction score

Patient satisfaction regarding pain control (0 = completely dissatisfied, 10 = fully satisfied). Higher scores indicate better satisfaction.

Time frame
1 hour postoperative

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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