Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy

ConditionCraniotomy Surgery

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-65

SponsorAssiut University

About this trial

To compare the intraoperative effects of Dexmedetomidine and Magnesium Sulfate infusion on intracranial pressure and cerebral perfusion pressure in adult patients undergoing craniotomy

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18-65 years

Elective craniotomy for supratentorial pathology

No contraindication to lumbar drain insertion

Baseline mental status is stable, allowing for a reliable postoperative neurological evaluation can be done

Disqualifiers

Coagulopathy or current anticoagulation

Severe renal or hepatic dysfunction

Known allergy to study medications

traumatic brain injury

Trial design

Design model

Parallel

Treatments tested in this trial

Dexamedomedine
Drug
Group A (the Dexmedetomidine group): Dexmedetomidine: loading dose 1 µg/kg IV over 10 min after induction and then maintenance dose 0.2- 0.7 µg/kg/hr based on hemodynamic response.
MgSO4
Drug
Magnesium Sulfate: Used as an IV loading dose at 20 mg/kg IV over 17 minutes as an induction agent, followed by maintenance of 10 mg/kg/h

Treatment groups

60 Participants

are divided into 2 treatment groups

Group A: DexmedetomidineActive comparator 1 intervention

Group B: Mgso4Active comparator 1 intervention

Trial outcomes

Primary outcomes

Change in ICP and CPP in craniotomy

compare the intraoperative intracranial pressure (ICP) and cerebral perfusion pressure (CPP) effects of dexmedetomidine and magnesium sulfate infusion in a comparative study to determine the efficacy in adult patients undergoing craniotomy, continuous measurement was achieved with the help of a lumbar drain catheter.

Time frame

o Pre-loading o After loading o Once the patient is in position (other than baseline) o After 30 min of incision (or every 30-60 min till skin closure)

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

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