For the patients with cervical persistent infection or integration of HPV, we has designed a program to perform cervical conization for certain patients to earlier and better diagnose and cure the diseases of HPV infection and related cervical intraepithelial neoplasia/cancer.
The patients are referred to colposcopy and biopsy examinations due to abnormal cervical screening results with no precancerous lesions discovered by pathology.
The course of HPV type 16/18 persistent infection is more than two years.
The integration reads of HPV is more than 15.
The impression of colposcopy indicates precancerous lesions.
Pregnant women.
Vaginal intraepithelial neoplasia is highly suspected by colposcopy and pathological examinations.
The patients are suffering malignant tumors of other system and have not been cured.
There is acute inflammation of the lower genital or anal tract.
Single group
diagnostic cervical conization
Procedure/SurgeryFor the patients who met the inclusion criteria, the gynecologists perform cervical conization and pathological examinations. Then the patients will be followed-up for at least two years with the tests of cervical TCT \& HPV, and colposcopy if necessary. The data will be analyzed and see if the patients with high risk factors benefit from the surgery or not.
The incidence of discovering concealed cervical cancer or percancerous lesions
The pathological examinations of the cervical conization might discover some concealed cervical cancer or precancerous lesions which could not be discovered by biopsy guided by colposcopy.
The incidence of HPV clearance after the cervical conization
After the cervical conizations, the patients will be arranged for follow-up every six months and HPV will be tested to see if the virus is cleared or not
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Tongji Hospital
Lead sponsor
National Natural Science Foundation of China
Collaborator
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