Diagnostic Feasibility of 100 Hz Tetanic Stimulation
ConditionPolyneuropathies
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorUniversity of Debrecen
About this trial
The goal of this observational study is to investigate the applicability of 100 Hz tetanic stimulation with an electromyography device in the exclusion of postoperative residual neuromuscular block. The aim is to determine whether fatigue develops with 100 Hz tetanic stimulation in anaesthetized, non-relaxed patients with normal or abnormal baseline electroneurographic (ENG) findings.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
ASA 1-3;
BMI 18.5-25 (normal body weight);
patient is in supine position with one arm accessible.
Disqualifiers
diseases with impaired neuromuscular function (myopathies, severe liver and kidney failure);
drugs affecting neuromuscular function (magnesium, aminoglycosides);
pregnancy (pregnancy tests are carried out in women of childbearing age to rule out pregnancy);
breast-feeding;
Trial population
Surgical patients
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
40 Participants
are grouped into 2 trial groupsGroup A: Normal ENG
Group B: Abnormal ENG
Trial outcomes
Primary outcomes
1
100 Hz tetanic fade response of abductor digiti minimi muscle to ulnar nerve stimulation in patients with normal and abnormal ENG
Electroneurography response of the abductor digiti minimi muscle to 100 Hz tetanic stimulation (tetanic fade) is examined to find out if there is difference in patients with or without polyneuropathy. Tetanic fade is the decrease of the twitch heights of the compound muscle action potential due to depletion of cetylcholin stores in the nerve terminal during tetanic stimulation.
Time frame
From enrollment until end of anesthesia asessed up to 1 hour. No further ENG measurements are performed in the postoperative period.Secondary outcomes
1
Diagnostic feasibility of electromyography in the examination of safety margin
To see whether tetanic stimulation with electromyography can be used as a routine tool to examine the safety margin and residual neuromuscular block. It is expected that there will be no fade in muscle response to 60 Hz tetanic stimulation in either groups. It is suspected that there will be no tetanic fade response to 100 Hz tetanic stimulation in patinets with normal ENG, however patinets with abnormal baseline ENG will produce tetanic fade. The incidence and extent of tetanic fade response will be examined.
Time frame
From enrollment until end of anesthesia assessed up to 1 hour. No further ENG measurements are performed in the postoperative period.Other outcomes
1
60 Hz tetanic fade response of abductor digiti minimi muscle to ulnar nerve stimulation in patients with normal and abnormal ENG
Electroneurography response of the abductor digiti minimi muscle to 60 Hz tetanic stimulation (tetanic fade) is examined to find out if there is difference in patients with or without polyneuropathy. Tetanic fade is the decrease of the twitch heights of the compound muscle action potential due to depletion of cetylcholin stores in the nerve terminal during tetanic stimulation.
Time frame
From enrollment until end of anesthesia assessed up to 1 hour. No further ENG measurements are performed in the postoperative period.Sponsors and contacts
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Source ClinicalTrials.gov