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Diet and WB-EMS Effects in Obesity

ConditionsObesity & OverweightMetabolic DisordersElectrotherapy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorFirat University

About this trial

Obesity is a major global health problem associated with metabolic dysfunction, altered adipokine signaling, and impaired appetite regulation. Conventional weight loss strategies such as calorie restriction often result in compensatory physiological adaptations, including increased appetite and loss of lean body mass, which may limit long-term effectiveness.

Whole-body electromyostimulation (WB-EMS) is an emerging, time-efficient intervention that induces simultaneous muscle activation and may improve metabolic health. However, the underlying molecular mechanisms, particularly the interaction between myokines and adipokines, remain insufficiently understood.

This randomized controlled trial aims to investigate the effects of an energy-restricted diet combined with WB-EMS on myokine-adipokine interaction, appetite regulation, and body composition in obese individuals. Participants will be randomly assigned to either a diet-only group or a diet plus WB-EMS group for 8 weeks.

Primary outcomes include changes in serum irisin levels. Secondary outcomes include myostatin, leptin, adiponectin, FGF-21, ghrelin, GLP-1, body composition parameters, and eating behavior. The findings of this study are expected to provide novel insights into the physiological and molecular effects of WB-EMS as a complementary strategy in obesity management.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age between 18 and 65 years

Body mass index (BMI) ≥ 30 kg/m²

Sedentary lifestyle (less than 2 hours of structured exercise per week)

Willingness to participate and provide written informed consent

Disqualifiers

Presence of pacemaker or implantable cardioverter-defibrillator

Known cardiovascular disease or severe chronic illness

Pregnancy or breastfeeding

Uncontrolled diabetes or severe metabolic disorders

Trial design

Design model

Parallel

Treatments tested in this trial

  • Energy-Restricted Diet

    Behavioral

    A personalized diet with approximately 750 kcal/day energy deficit.

  • Whole-Body Electromyostimulation (WB-EMS)

    Device

    Whole-body electromyostimulation applied 2-3 times per week for 8 weeks under supervision.

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: Diet OnlyActive comparator 1 intervention
Group B: Diet + WB-EMSExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Change in serum irisin levels

Assessment of change in circulating irisin levels measured by ELISA.

Time frame
Baseline to 8 weeks

Secondary outcomes

1

Change in serum myostatin levels

Assessment of change in circulating myostatin levels measured by ELISA.

Time frame
Baseline to 8 weeks
2

Change in serum leptin levels

Assessment of change in circulating leptin levels.

Time frame
Baseline to 8 weeks
3

Change in serum adiponectin levels

Assessment of change in circulating adiponectin levels.

Time frame
Baseline to 8 weeks
4

Change in serum FGF-21 levels

Assessment of change in circulating fibroblast growth factor-21 levels.

Time frame
Baseline to 8 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Firat University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: