Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversität Münster
About this trial
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
adult patients undergoing on- or off-pump coronary artery bypass graft surgery
written informed consent
Disqualifiers
emergency surgery in the context of acute coronary syndrome
ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery
Chronic kidney disease with estimated glomerular filtration rate (eGFR)<30ml/min/1.73m²
Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis)
Trial population
University Hospital
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
on-pump surgery
Procedure/Surgerythe surgery will be performed "on-pump"
off-pump surgery
Procedure/Surgerythe surgery will be performed "off-pump"
Treatment groups
40 Participants
are divided into 2 treatment groupsGroup A: on-pump coronary artery bypass graft surgery1 intervention
Group B: off-pump coronary artery bypass graft surgery1 intervention
Trial outcomes
Primary outcomes
1
Differences in plasma concentration of Angiotensinogen
Time frame
between induction of anesthesia and immediately after surgical intervention2
Differences in plasma concentration of Renin
Time frame
between induction of anesthesia and immediately after surgical intervention3
Differences in plasma concentration of Angiotensin I
Time frame
between induction of anesthesia and immediately after surgical intervention4
Differences in plasma concentration of Angiotensin converting enzyme (ACE)
Time frame
between induction of anesthesia and immediately after surgical interventionSecondary outcomes
1
Differences in plasma concentration of Angiotensin 1-9
Time frame
between induction of anesthesia and immediately after surgical intervention2
Differences in plasma concentration of Angiotensin 2-7
Time frame
between induction of anesthesia and immediately after surgical intervention3
Differences in plasma concentration of Dipeptidyl-peptidase 3 (DPP3)
Time frame
between induction of anesthesia and immediately after surgical intervention4
Incidence of vasoplegia
Time frame
within 12 hours post surgerySponsors and contacts
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Source ClinicalTrials.gov