Differential Study of Invasive Pituitary Adenomas in the Sellar and Cavernous Sinus Regions
ConditionPituitary Tumor
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorShanghai Zhongshan Hospital
About this trial
This study involves collecting paired tumor samples from intrasellar and cavernous sinus regions of 20 invasive pituitary tumor patients, preserving them at -80°C for quality multi-omics analysis. Proteomics and transcriptomics are employed to identify molecular differences, while imaging data (MRI/CT) assesses tumor morphology and invasion. In vitro experiments and mechanistic studies validate key findings, exploring how regional molecular differences affect tumor behavior. Data integration combines multi-omics and imaging features to uncover biomarkers and pathways associated with invasiveness and regional specificity, with statistical analysis ensuring significance and reliability.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Invasive pituitary tumors involving the cavernous sinus
Retrospective inclusion of patients who have signed informed consent forms for the donation of biological samples and health-related information
Age range: 18-80 years
Subjects are willing to participate in this study
Disqualifiers
Non-invasive pituitary tumors
Pregnant or breastfeeding
Other conditions deemed unsuitable for participation in this clinical trial as assessed by the physician
Trial population
Patients aged 18-80 years who are clinically diagnosed with invasive pituitary tumors involving the cavernous sinus, have signed the informed consent form, and are willing to participate in this study.
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
surgery
Other interventionSamples were obtained from patients by surgical excision and matched into groups
Treatment groups
20 Participants
are divided into 2 treatment groupsGroup A: pituitary tumors in cavernous sinus group1 intervention
Group B: pituitary tumors in sellar group1 intervention
Trial outcomes
Primary outcomes
1
Differences in pathological features of tumors
Cell morphology, proliferation index (e.g. Ki-67), angiogenesis, and other pathological features of tumor tissue in different regions were analyzed to explore region-specific invasive manifestations
Time frame
2025/12/01-2026/12/01Sponsors and contacts
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Source ClinicalTrials.gov