The purpose of this study is to assess the digestion and absorption kinetics of beef consumed alone or as part in healthy adults. In a randomized, crossover design, 10 young, healthy adult males and females aged 18-35 years, will consume a meal consisting of 25 g protein from minced beef alone or as part of a mixed-meal during two separate experimental trials. The main study endpoint is the exogenous rate of amino acid appearance in response to the ingested beef over a 10-h period.
Aged between 18-35 years
BMI between 18.5-30 kg/m2
Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)
No physical limitations (i.e., able to perform all activities associated with daily living independently)
Smoking
Vegan, vegetarian, or does not consume beef protein
Diagnosed musculoskeletal disorders
Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications)
Crossover
Food proteins
Dietary supplementMeal consisting of 25 g protein･kg BM-1 from minced beef protein.
Digestion and absorption kinetics
The exogenous rate of amino acid appearance in response to the ingested beef (expressed as μmol/kg/min). Based on tracer plasma amino acid concentrations over time (measured with ultra performance liquid chromatography-mass spectrometry).
Whole-body protein metabolism
Whole-body protein metabolism includes measurements of protein synthesis, breakdown, oxidation, and net balance (all expressed as μmol/kg/h). Based on amino acid concentrations in plasma and breath samples over time (measured with ultra performance liquid chromatography-mass spectrometry and gas chromatography-isotope ratio mass spectrometry).
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