Digital App for Speech & Health Monitoring
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age16+
SponsorUniversity of Edinburgh
About this trial
Many people living with neurodegenerative conditions like dementia, motor neuron disease (MND), multiple sclerosis (MS), and Parkinson's disease (PD), suffer from speech problems. Using common digital technologies such as smartphone apps, the investigators can record and analyse speech in detail to provide new information for people living with these conditions, researchers, and healthcare professionals. This study will investigate the use of these digital speech recordings to help diagnose and monitor these conditions.
To take part, participants will have either a diagnosis of dementia, motor neuron disease, Parkinson's disease or Multiple Sclerosis, OR they will have no diagnosis of a neurological condition. Researchers will compare people with a diagnosis of a Neurological condition to those without.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
A person with a diagnosis of Motor Neuron Disease, Dementia, Multiple Sclerosis, or Parkinson's Disease.
A relative or carer of the above who does not report to have a neurological condition.
A healthy volunteer who does not report to have a neurological condition.
Disqualifiers
Age <16 years
Significant and uncorrected visual or hearing impairment (precluding use of the App).
Lack capacity to consent to project due to cognitive impairment (precluding understanding of the study and use of the App).
Trial population
Participants with Neurodegenerative Disorders and their relatives or carers without a diagnosis of a Neurodegenerative disorder.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
150 Participants
are grouped into 5 trial groupsGroup A: Carers/Realtives/ Healthy - No Diagnosis of a Neurodegenerative Disorder
Group B: Motor Neuron Disease
Group C: Multiple Sclerosis
Group D: Dementia
Group E: Parkinson's Disease
Trial outcomes
Primary outcomes
1
Primary outcome measures
Area under the curve (AUC) of the receiver operating characteristic (ROC) curve for each of the 4 binary classifiers distinguishing between a disease-positive group and a healthy control group.
Time frame
24 monthsSecondary outcomes
1
Secondary outcome measure
Sensitivity, specificity, positive and negative predictive values for each of the 4 binary classifiers distinguishing between a disease-positive group and a healthy control group.
Time frame
24 months2
Secondary outcome measure
Mean squared error of 4 regression models making predictions of condition-specific clinical rating scores (ACE-III, ALSFRS-R, EDSS, MDS-UPDRS)
Time frame
24 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Edinburgh
Lead sponsor
NHS Lothian
Collaborator
Source ClinicalTrials.gov