Health Trials

Digital Interventions to Increase HPV Vaccination Intentions Among Nigerian Caregivers

ConditionsHPVHPV Vaccine
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age27+
SponsorUniversity of Pennsylvania

About this trial

This study evaluates whether different types of digital health communication can increase parents' intention to vaccinate their daughters against human papillomavirus (HPV) in Nigeria. HPV vaccination is recommended for girls aged 9-14 years and helps prevent cervical cancer, yet vaccination rates remain low.

Parents of eligible, unvaccinated girls will be randomly assigned to receive one of several types of digital content delivered online. These include: (1) a short chatbot conversation based on motivational interviewing principles, (2) an interactive game designed to help parents recognize and resist common forms of vaccine misinformation, (3) a set of short edutainment videos about HPV vaccination, (4) standard informational infographics about HPV vaccination from a national public health agency, or (5) unrelated health content about menstruation.

The main outcome is parents' self-reported intention to vaccinate their daughter against HPV, measured immediately and one week after exposure to the assigned content. Additional outcomes include HPV-related knowledge, perceptions of vaccine safety, willingness to recommend the vaccine to others, and self-reported vaccine uptake at 1-week and 6 month follow-up. The results will help inform scalable communication strategies to improve HPV vaccination uptake in low- and middle-income settings.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Parent or primary caregiver of at least one girl aged 9-14 years

Parent states "no" or "unsure" to question asking if eligible daughter has received any doses of the HPV vaccine

Provides informed consent to participate

Disqualifiers

Parent or caregiver of a girl who has already received one or more doses of the HPV vaccine

Does not meet age eligibility criteria for an eligible daughter

Fails Attention Checks

Trial design

Design model

Parallel

Treatments tested in this trial

  • Chatbot counseling

    Behavioral

    A brief motivational-interviewing-style chatbot dialogue adapted from WHO vaccination counseling guidance

  • Misinformation-resistance pre-bunking inoculation

    Behavioral

    A short interactive game (approximately 3-5 minutes) designed to build resistance to HPV vaccine misinformation

  • Short edutainment

    Behavioral

    5-6 brief edutainment videos (total viewing time approximately 10-15 minutes) providing HPV vaccine information tailored to the Nigerian context

  • Standard infographic control

    Behavioral

    Existing infographics on HPV vaccination from Nigeria's National Primary Health Care Development Agency (NPHCDA)

Treatment groups

3,340 Participants
are divided into 5 treatment groups
Group A: Chatbot counseling armExperimental treatment 1 intervention
Group B: Misinformation-resistance pre-bunking inoculation armExperimental treatment 1 intervention
Group C: Short edutainment armExperimental treatment 1 intervention
Group D: Standard infographic control armActive comparator 1 intervention
Group E: Unrelated content control armNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

HPV Vaccination Intention (1-Week Post-Intervention)

Parent's self-reported intention to vaccinate their selected daughter (aged 9-14 years) against HPV, measured on a 10-point numeric scale, where higher values indicate greater intention to vaccinate. If a participant has more than one eligible daughter, one daughter is randomly selected for all outcome questions.

Time frame
1 week after exposure to the assigned intervention content
2

HPV Vaccination Intention (Immediately Post-Intervention)

Parent's self-reported intention to vaccinate their selected daughter against HPV, measured on a 10-point numeric scale.

Time frame
Immediately Post-Intervention

Secondary outcomes

1

HPV Vaccination Intention (6 months post-intervention)

Parent's self-reported intention to vaccinate their selected daughter against HPV, measured on a 10-point numeric scale, assessed immediately after completion of the assigned intervention content.

Time frame
6 months post-intervention
2

Self-Reported HPV Vaccine Uptake

Parent's self-report of whether their selected daughter has received at least one dose of the HPV vaccine since participation in the study (yes/no).

Time frame
6 months post-intervention
3

Perceived Safety of the HPV Vaccine

Parent's perceived safety of the HPV vaccine, measured using Likert-scale items assessing agreement with statements about HPV vaccine safety.

Time frame
1 week post-intervention, 6 months post-intervention
4

Likelihood of Recommending the HPV Vaccine to Other Parents

Parent's self-reported likelihood of recommending the HPV vaccine to other parents of eligible girls, measured on a Likert-type scale.

Time frame
1 week post-intervention, 6 months post-intervention

Other outcomes

1

Engagement With Assigned Intervention Content

Behavioral engagement metrics including completion status and time spent interacting with the assigned intervention content.

Time frame
During intervention exposure

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Pennsylvania

Lead sponsor

World Bank Group

Collaborator

Source ClinicalTrials.gov
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