About this trial
This study is a mixed-methods pilot designed to evaluate the feasibility, acceptability, and appropriateness of a brief digital micro-intervention aimed at reducing stigma-related barriers to pre-exposure prophylaxis (PrEP) engagement among people who use drugs (PWUD) in Kazakhstan. Participants will complete baseline and post-intervention surveys and receive structured informational content via Telegram or WhatsApp over approximately 2-3 weeks. The intervention focuses on addressing anticipated stigma, confidentiality concerns, and misinformation that may prevent PWUD from seeking PrEP services. No clinical procedures, medication provision, or biological specimen collection are involved.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Self-reported drug use within the past six months
HIV-negative or unknown HIV status (self-reported)
Not currently taking PrEP
Able to provide informed consent
Disqualifiers
Are unable to provide informed consent
Do not have access to a mobile device for digital message delivery
Are currently enrolled in another PrEP behavioral intervention study
Trial design
Single group
Treatments tested in this trial
Dgital micro-intervention
BehavioralIntervention will include 6-10 brief modules delivered asynchronously consisting of text-based content with optional simple visuals. There is no requirement for participant response. Messages will avoid explicit labeling referencing HIV or drug use in preview text and be written using neutral language. Participants are allowed to discontinue receipt at any time.
Treatment groups
Trial outcomes
Primary outcomes
Mean Score Acceptability of Intervention Measure (AIM)
Acceptability of the intervention will be assessed using the Acceptability of Intervention Measure (AIM). It has 4-items scored on a 5-point Likert scale summed to achieve a total score. Total score range of 0-20. Higher scores indicate more acceptability.
Mean Score Intervention Appropriateness Measure (IAM)
The Intervention Appropriateness Measure (IAM) is a 4-item, 5-point Likert scale ( 1=Completely Disagree to 5=Completely Agree) used to evaluate the perceived fit, relevance, or compatibility of an intervention or implementation strategy. Total score range 0-20. Higher scores indicate better appropriateness.
Mean Score Feasibility of Intervention Measure (FIM)
Feasibility of intervention measured using Feasibility of Intervention Measure (FIM)- a 4-item instrument to assess perceived intervention feasibility. Total score 1-5 with higher scores indicating greater feasibility.
Secondary outcomes
Change in PrEP knowledge
Measured by a structured survey. Total score range 1-10. Higher scores indicate increased knowledge.
Change in perceived stigma-related barriers
Measured by a structured survey. Total score range 8-40. Higher scores indicate more barriers.
Change in readiness to seek PrEP
Measured by Likert scale survey items. Total score range 1-5. Higher scores indicate increased readiness.
Mean number of clicks or links accessed
Mean number of clicks or links accessed among participants that used the intervention
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Yale University
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator
This trial is not recruiting at the moment. You can still explore other options: