Digital Voice Analysis as a Measure of Frailty and Distress
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital, Basel, Switzerland
About this trial
This study evaluates if it is possible to identify quantitative parameters from audio signals to describe the changes in patient's state in relation to frailty and distress.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Active cancer or haemato-oncological malignancy
Adults (≥ 18 years)
Ability to understand, speak and read German language fluently
Ability to provide written consent
Disqualifiers
Aphonia, dysphonia or other obvious voice alterations of patient's voice
Life-expectancy shorter ≤ 14 days as judged by a physician or nurse via "surprise question"
Breathlessness whilst speaking
Cognitive impairment as judged by physician or Mini-Cog in the G8 screening tool
Trial population
Patient recruitment will be performed at the different participating clinical sites by the investigator
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Data acquisition: Speech acquisition
Other interventionSpeech test with synchronized audio and video recording. The speaking exercises and the audio and video recording will be done using a tablet computer and an application developed in-house. Freely available images showing different scenes will be integrated and displayed on the tablet to be described by the patient. The goal is to have at least two and maximum four of them described with several sentences by each patient per session. Parameters will be extracted from the patient's audio data to estimate the changes in distress and frailty.
Data acquisition: G8 Screening tool
Diagnostic testThe G8 screening tool consists of seven items dealing with food intake, weight loss, mobility, neuropsychological problem, body mass index, prescription drug, and self-perception of health, from the Mini-Nutritional Assessment (MNA) questionnaire and was developed specifically for elderly cancer patients. The total G-8 score lies between 0 and 17. A higher score indicates a better health status.
Data acquisition: Distress Thermometer
Diagnostic testThe distress thermometer (DT) is a measure of psychological distress in cancer patients. The instrument is a self-reported tool using a 0-to-10 rating scale.
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: Cohort A: palliative care center3 interventions
Group B: Cohort B: mid-size cancer center3 interventions
Trial outcomes
Primary outcomes
1
Change of mean fundamental frequency extracted from the patient's audio data
Change of mean fundamental frequency extracted from the patient's audio data to estimate the changes in distress and frailty.
Time frame
during a 16-week period for each patient2
Change of first few formants (F1, F2)
Change of first few formants (F1, F2) extracted from the patient's audio data to estimate the changes in distress and frailty.
Time frame
during a 16-week period for each patient3
Change of jitter (variation in F0 from cycle to cycle)
Change of jitter (variation in F0 from cycle to cycle) extracted from the patient's audio data to estimate the changes in distress and frailty.
Time frame
during a 16-week period for each patient4
Change of shimmer (variation in peak-to-peak amplitude)
Change of shimmer (variation in peak-to-peak amplitude) extracted from the patient's audio data to estimate the changes in distress and frailty.
Time frame
during a 16-week period for each patientSponsors and contacts
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Source ClinicalTrials.gov