Diuretic Testing in Chronic Kidney Disease

ConditionKidney Disease, Chronic

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorErasmus Medical Center

About this trial

The goal of this clinical trial is to predict the progression of chronic kidney disease by diuretic testing in patients with chronic kidney disease. The main questions it aims to answer are:

Does a worse result of a diuretic test predict the progression of chronic kidney disease?

If there is a comparison group: Researchers will compare the diuretic test in patients with chronic kidney disease to healthy participants to see if the results are different in a healthy kidney.

Participants will undergo diuretic testing. This involves the administration of bumetanide and hydrochlorothiazide with subsequent blood and urine collections.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

CKD stage G3 (creatinine-based eGFR 30-59 mL/min/1.73m2) during the last outpatient visit

Disqualifiers

Known intolerance or allergy to the diuretics

Current systemic chemotherapy for malignancy

Kidney transplant recipient

Use of calcineurin-inhibitors

Trial design

Design model

Parallel

Treatments tested in this trial

Diuretic Testing
Diagnostic test
The administration of hydrochlorothiazide and bumetanide is used to stimulate and assess tubular function.

Treatment groups

86 Participants

are divided into 2 treatment groups

Group A: Diuretic GroupExperimental treatment 1 intervention

Group B: Time control groupNo intervention 0 interventions

Trial outcomes

Primary outcomes

Progression of Chronic Kidney Disease

This composite outcome consists of the reduction of kidney function of 30% measured as creatinine-based estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration (CKD-EPI) 2021 formula or the initiation of kidney replacement therapy (dialysis or kidney transplantation)

Time frame

3 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Erasmus Medical Center

Lead sponsor

European Research Council

Collaborator

Source ClinicalTrials.gov

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