DNA Methylation and the Increased Risk of Cervical Cancer Development
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age15-50
SponsorZhujiang Hospital
About this trial
This study aims to investigate the correlation between reproductive tract microbiota and DNA methylation in cervical epithelial cells, as well as its impact on the development of cervical cancer, through a paired case-control clinical study
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Aged 18-50 years old, with a history of sexual activity
HPV and TCT tests are performed concurrently in the gynecology clinic
Those with abnormal HPV and TCT test results undergo tissue pathological testing
Disqualifiers
Pregnant or breastfeeding
Patients with immunological disorders or severe autoimmune diseases, such as AIDS, SLE
Those who have had organ transplants or are currently using immunosuppressive agents
Use of vaginal douching within 48 hours before sample collection
Trial population
Women aged 18 to 50
Trial design
Design model
Case-control
Time perspective
Retrospective
Treatments tested in this trial
Reproductive tract microbiota
Other interventionReproductive tract microbiota
Treatment groups
2,000 Participants
are divided into 4 treatment groupsGroup A: control1 intervention
Group B: Case group 11 intervention
Group C: Case group 21 intervention
Group D: Case group 31 intervention
Trial outcomes
Primary outcomes
1
Changes in DNA methylation of cervical epithelial cells
Changes in DNA methylation of cervical epithelial cells
Time frame
Baseline (enrollment period)Secondary outcomes
1
Cervical lesions (including different stages of development: normal, CIN 1, CIN 2, CIN 3, and cervical cancer), and sexually transmitted pathogens
Cervical lesions (including different stages of development: normal, CIN 1, CIN 2, CIN 3, and cervical cancer), and sexually transmitted pathogens.
Time frame
Baseline (enrollment period)Locations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: