Does Paracetamol Influence the Release of Gut Hormones, Glucose Absorption and Glycemia?

ConditionsHealthy Young Adults Physiology

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorUniversity of Copenhagen

About this trial

The study aim is to determine whether acute inhibition of endogenous prostaglandin synthesis by paracetamol affects the release of gut hormones, glucose absorption and glycemia in healthy young individuals

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age ≥ 18 years

Nondiabetic fasting plasma glucose (< 7.0 mmol/L) at time of inclusion

BMI of 20-25

Written informed consent

Disqualifiers

Haemoglobin < 7.9 mmol/L

Pregnancy or breastfeeding

Significant gastrointestinal symptoms (e.g. dyspepsia, postprandial pain)

Use of medication that cannot be paused for 12 hours or any drug that affects gastric emptying, small intestinal motility, glucose absorption.

Trial design

Design model

Crossover

Treatments tested in this trial

Paracetamol
Other intervention
Paracetamol is used as a tool to block prostaglandin synthesis
Placebo
Other intervention
A placebo will be administered to be able to determine the effect of paracetamol on prostaglandin synthesis

Treatment groups

12 Participants

are divided into 2 treatment groups

Group A: Paracetamol (1000mg)Active comparator 1 intervention

Group B: PlaceboPlacebo comparator 1 intervention

Trial outcomes