Does Sexual Intercourse Affect the Outcomes of Frozen-thawed Embryo Transfer?
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-41
SponsorSheba Medical Center
About this trial
The goal of this clinical trial is to test whether sexual intercourse the night after embryo transfer affects thawed embryo implantation rates. Women undergoing one of their first four frozen embryo transfers with a good quality embryo will be randomly assigned to two groups. The study group is subjected to have intercourse without using a condom at the evening/night after the embryo transfer, while the control group will abstain from intercourse for the next 48 hours after the transfer. Researchers will compare the ongoing pregnancy rates between the intervention group and the control group.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Women age 18-41yrs.
BMI (body mass index) of 18-35 kg/m².
Patients undergoing one of their first four frozen embryo transfers.
Patients transferring a good quality embryo, either a cleavage stage embryo or a day 5 blastocyst.
Disqualifiers
Patients age above 42.
Moderate or poor-quality embryos.
Patients with hydrosalpinx or uterus malformations.
Patients who are not able or are not interested in having vaginal intercourse (same sex couples for example).
Trial design
Design model
Parallel
Treatments tested in this trial
Sexual intercourse
BehavioralSexual intercourse without barrier contraceptive at the evening/night after the embryo transfer
Treatment groups
656 Participants
are divided into 2 treatment groupsGroup A: Assigned to intercourseExperimental treatment 1 intervention
Group B: Assigned to abstainNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Ongoing pregnancy rate
Ultrasound showing a fetus with a heartbeat
Time frame
At 6 week of gestation (4 weeks after embryo transfer)Secondary outcomes
1
Biochemical pregnancy rate
Positive BHCG blood test
Time frame
12-14 days after the embryo transfer2
Clinical pregnancy rate
Ultrasound confirmation of an intrauterine gestational sac
Time frame
At 6 week of gestation (4 weeks after embryo transfer)Sponsors and contacts
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Source ClinicalTrials.gov