Doppler Echocardiography Versus Clinical Targets Guided Therapy on the Outcome of Postpartum Septic Shock.

ConditionsDoppler Echocardiography Postpartum Septic Shock

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexFemale

Age18-45

SponsorAssiut University

About this trial

Postpartum sepsis is widely known as a preventable main cause of maternal morbidity and mortality. According to the World Health Organization, approximately 11% of the estimated maternal deaths worldwide were attributed to sepsis. Recent global assessments indicate that obstetric infections rank as the third most prevalent cause of maternal death, with a prevalence mainly observed in low- and middle-income nations.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

postpartum women, within 6 weeks following delivery

meeting the third international consensus definitions for septic Shock (2016) (Sepsis-3): acute persisting hypotension requiring vasopressors to maintain mean arterial pressure (MAP) ≥ 65 mm Hg and having a serum lactate > 2 mmol/L (18 mg/dL) despite adequate volume resuscitation

Disqualifiers

Patient refusal

History of any chronic cardiac disease

Requirement for immediate surgery

Hypotension attributable to another cause

Trial design

Design model

Parallel

Treatments tested in this trial

a clinically guided resuscitation protocol,
Procedure/Surgery
a clinically guided resuscitation protocol, derived from EGDT and modified to match with the latest survival sepsis campaign guidelines
a transthoracic bedside focused echocardiographic assessment
Procedure/Surgery
a transthoracic bedside focused echocardiographic assessment of the patient will be done, as a baseline ECHO in a three-step approach to monitor hemodynamics using Logiq P7, S5-1 ECHO probe;

Treatment groups

60 Participants

are divided into 2 treatment groups

Group A: CTGT groupExperimental treatment 1 intervention

Group B: ECHO groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

SOFA score

The change in Sequential Organ Failure Assessment (SOFA score)

Time frame

48 hours.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: