This study examines in hospitalized patients, treated with sulfamethoxazole, high dose ciprofloxacin or high dose iv amoxicillin, the incidence of drug-induced urinary crystal formation and its association with acute kidney injury development.
Age ≥ 18 years
Able to give informed consent without the intervention of a legal representative
Treatment with
sulfamethoxazole/trimethoprim, with minimum dose of
Unable to give informed consent without the intervention of a legal representative
No baseline renal function up to 72 hours prior to the start of antibiotic treatment available, evaluated by serum creatinine and eGFR (CKD-EPI)) for all study groups and additional serum urea for the sulfamethoxazole group.
Treatment duration < 24 hours or insufficiently long to perform one crystalluria inves-tigation as defined in the protocol
Patients treated with hemodialysis or peritoneal dialysis, anuric patients before start of antibiotic treatment