Health TrialsbyHealthPanel

Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank

ConditionsDry Eye SyndromeSjogren's SyndromeHealthy ControlInflammation
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-75
SponsorTaipei Veterans General Hospital, Taiwan

About this trial

The comprehensive analysis of health records, TCM constitution, biomarker, and whole-genome sequencing among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease in Taiwan: an integrated analysis between Taiwan Biobank and Sjögren's syndrome Database

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

aged between 20 and 75 years

fulfilled the 2002 American-European Consensus Criteria for SS (AECG)

Disqualifiers

aged between 20 and 75 years

Schirmer's test less than 10 mm/5 min Exclusion Criteria: NA

aged between 20 and 75 years

Disease diagnosed with Inflammation Exclusion Criteria: NA

Trial population

Health Subjects Inclusion Criteria: 1. aged 20 and 75 years 2. had no chronic inflammatory illness. Exclusion Criteria: 1. a history of alcohol abuse, diabetes mellitus, or major life-threatening condition 2. pregnancy or breastfeeding 3. abnormal findings of immune, liver, kidney, or blood function evaluations 4. total sleeping time insufficiency less than 6 hours before one day of enrollment 5. ever took the conventional medicine or hormone within one month 6. ever encountered the acute illness, allergy reaction, immune, or rheumatic disease within one month.

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

  • Whole-genome genotyping

    Diagnostic test

    Using Whole-genome genotyping from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease.

  • Whole-genome sequencing

    Diagnostic test

    Using whole-genome sequencing from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.

  • TCM pattern

    Diagnostic test

    We want to use TCM pattern to investigate the difference among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease.

  • DNA Exome sequencing

    Diagnostic test

    The DNA of dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease will take to do the DNA Exome sequencing.

  • Physical examination indicators, blood, urine and biochemical function test

    Diagnostic test

    To investigate the difference of Physical examination indicators, blood, urine and biochemical function test among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease.

  • Demographics, personal health behavior, living environment, dietary status, family history

    Diagnostic test

    To investigate the difference among the demographics, personal health behavior, living environment, dietary status, family history of among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease.

  • HLA typing

    Diagnostic test

    Using HLA typing from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.

  • Full-length 16S Amplicon Sequencing

    Diagnostic test

    Using Full-length 16S Amplicon Sequencing from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.

  • Epigenomic

    Diagnostic test

    Using Epigenomic from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.

  • Metabolomics

    Diagnostic test

    Using Metabolomics from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.

  • Environmental Toxic

    Diagnostic test

    Using Environmental Toxic from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.

  • Medical Image

    Diagnostic test

    Using Medical Image from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.

Treatment groups

100,000 Participants
are divided into 4 treatment groups
Group A: Dry eye syndrome12 interventions
Group B: Health subjects12 interventions
Group C: Sjögren's syndrome12 interventions
Group D: other inflammation disease12 interventions

Trial outcomes

Primary outcomes

1

Immunity-related gene expression

To evaluate the immunity-related gene expression for Dry eye syndrome, Sjögren's syndrome and healthy control. DNA exome combine the GATK (Genome Analysis Toolkit) is a tool for detecting the ratio of immunity-related gene expression.

Time frame
Five year
2

TCM pattern

To evaluate the difference of TCM pattern between Dry eye syndrome, Sjögren's syndrome and healthy control. TCM pattern is a tool for detecting the constitution.

Time frame
Five year

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Taipei Veterans General Hospital, Taiwan

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: