Health TrialsbyHealthPanel

DTI & DIR in Optic Neuritis

ConditionOptic Nerve Disease
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University

About this trial

To evaluate the role of Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI) in the assessment of optic neuritis and to correlate imaging findings with clinical and visual outcomes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age above 18 years.

Clinically suspected optic neuritis.

Evidence of multiple sclerosis or other demyelinating diseases.

Disqualifiers

Traumatic optic neuritis.

Systemic diseases affecting the optic nerve.

Contraindications to MRI.

Trial population

Adults with clinically suspected optic neuritis referred for MRI evaluation, together with healthy control participants.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • MRI

    Device

    DTI and DIR

Treatment groups

56 Participants
are divided into 2 treatment groups
Group A: Healthy controls1 intervention
Group B: Optic Neuritis Patients1 intervention

Trial outcomes

Primary outcomes

1

Fractional anisotropy (FA) value of the affected optic nerve measured by diffusion tensor imaging (DTI)

Fractional anisotropy (FA) values will be calculated from regions of interest placed along the affected optic nerve and compared between participants with optic neuritis and healthy controls.

Time frame
Baseline At the time of MRI examination
2

Mean diffusivity (MD) value of the affected optic nerve measured by diffusion tensor imaging (DTI)

Mean diffusivity (MD) values will be calculated from regions of interest placed along the affected optic nerve and compared between participants with optic neuritis and healthy controls.

Time frame
Baseline At Time of MRI examination

Secondary outcomes

1

Number of optic nerve lesions detected using Double Inversion Recovery MRI.

The number of optic nerve lesions identified on DIR images will be recorded for each participant.

Time frame
Baseline At Time of MRI examination

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: