Dynamic Functional Imaging Phenotyping and Disease Progression Risk Assessment in COPD Using Dynamic Chest Radiography: A Multicenter Retrospective Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30-85
SponsorNanfang Hospital, Southern Medical University

About this trial

To evaluate the utility of DCR-derived parameters for identifying dynamic functional imaging phenotypes, assessing disease severity, and predicting the risk of disease progression in COPD.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged 30-85 years.

Male or female.

Patients who underwent pulmonary function testing and dynamic chest radiography at the hospital.

Disqualifiers

Incomplete medical records.

Considered unsuitable for inclusion in the study at the investigator's discretion.

Trial population

Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms, including dyspnea, cough, and sputum production. These symptoms result from airway abnormalities, such as bronchitis or bronchiolitis, and/or alveolar abnormalities, such as emphysema, that cause persistent and often progressive airflow obstruction.

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

Not listed

Trial groups

2,500 Participants
are grouped into 4 trial groups
Group A: COPD group
Group B: PRISM group
Group C: Smoking exposure groups
Group D: Normal control group

Trial outcomes

Primary outcomes

1

Exacerbation/respiratory history and event

Measurement of disease control and burden

Time frame
At Baseline
2

FEV1 %

Measurement of lung function

Time frame
At Baseline
3

FEV1 /FVC

Measurement of lung function

Time frame
At Baseline
4

Emphysema

Measurement of chest CT

Time frame
At Baseline

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Nanfang Hospital, Southern Medical University

Lead sponsor

The First Affiliated Hospital of Guangzhou Medical University

Collaborator

Qingyuan People's Hospital

Collaborator