DYNAMic Renal Assessment: NOvel Methods to Assess KIDNEY Functional Reserve
ConditionChronic Kidney Diseases
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40+
SponsorKing's College Hospital NHS Trust
About this trial
This is a feasibility study to assess new, more practical ways of measuring renal reserve.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patients with sickle cell nephropathy, diagnosed clinically or histologically. Sickle Cell patients will be confirmed Hb SS and eGFR (CKD-EPI) ≥ 135 ml/min/1.73m2 OR
Previous living kidney donation
Age ≥ 4No contraindication or known allergy to any trial medications.
Willing and able to provide written informed consent
Disqualifiers
None
Trial population
: 44 Participants
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
Dapagliflozin
DrugOn Day 3 to 16, participants will take 10mg dapaglifozin (SGLT-2 inhibitor) orally once daily.
Treatment groups
44 Participants
are divided into 2 treatment groupsGroup A: Healthy Participants1 intervention
Group B: Patients with hyperfiltration1 intervention
Trial outcomes
Primary outcomes
1
Change in eGFR from baseline to 2hours after oral protein load
Time frame
2 hoursSponsors and contacts
Click on the lead sponsor to view all of their trials.
King's College Hospital NHS Trust
Lead sponsor
King's College London
Collaborator
Source ClinicalTrials.gov