Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorAssistance Publique - Hôpitaux de Paris
About this trial
Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adult or child planning to live in the same household as his/her dog during the three months following inclusion.
Planning to live in the same habitat in the next three months following inclusion (except for holidays).
Written consent of all adults and of at least one of the two parents for minors under parental authority. A different information note will be elaborated for each age category (6-10 yr-old, 10-15 yr-old and 16-18 yr-old).
Owning a dog recorded for a surgery at the National Veterinary School
Disqualifiers
Lack of signed informed consent
Subject in alternating custody
Subject under legal protection (guardianship)
Subject deprived of liberty under judicial constraint
Trial population
The healthy volunteers (dog owners) will be recruited at a single recruitment centre, which is the National Veterinary School (Maisons-Alfort).
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
human faecal collection
Other interventioncollecting stools 6 times over a 90 days period and complete a questionnaire at the same times: D1, D7, D15, D30, D60 and D90
ancillary study
Other interventioninterviews and/or ethnographic observations for 50 volunteers
Treatment groups
525 Participants
are divided into 1 treatment groupGroup A: household2 interventions
Trial outcomes
Primary outcomes
1
generation of a list of priorities for future prevention and control strategies to mitigate antimicrobial resistance (AMR) transmission between companion animals and humans
mathematical models combining all the data (epidemiological, bacteriological, genomic, sociological) gathered in the project
Time frame
over the 90 days follow upSecondary outcomes
1
Rates of AMR acquisitions in one or several housekeepers
Time frame
over the 90 days follow up2
A list in nature of changes in dog microbiota
Time frame
over the 90 days follow up3
A list in magnitude of changes in dog microbiota
Time frame
over the 90 days follow up4
A list in nature of changes in housekeepers microbiota
Time frame
over the 90 days follow upSponsors and contacts
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Source ClinicalTrials.gov