Patients requiring admission to the hospital due to a moderate and severe COVID-19 infection may differ in their ability to respond to viral infection and to eliminate viral load.
Several comorbidities and interventions like antivirotic or antiinflammatory treatment may also modify expected patients response and decrease of viral load.
In this observational study, evolution of selected inflammatory markers, indicators of severity of infection and patient characteristics will be followed and recorded in hospitalized patients with COVID-19.
SARS CoV2 positive test within last 14 day
bilateral infiltrates on chest X.ray or CT
need for oxygen to keep pulse oximetry saturation above 92% or other respiratory support measures (HFNO, non-invasive ventilation or invasive ventilation)
known history of intersticial lung disease
known history of congestive heart failure
Hospitalized COVID-19 with moderate to severe course of COVID-19 infection.
Cohort
Prospective
Not listed
Prediction of severity of lung dysfunction based on initial nucleocapsid antigen serum levels
Correlation between baseline nucleocapsid serum levels and the Ordinal Scale for Clinical Improvement
Prediction of severity of lung dysfunction based on initial interleukin-6 serum levels
Correlation between baseline interleukin -6 serum levels and Ordinal Scale for Clinical Improvement
Prediction of severity of lung dysfunction based on
Correlation between baseline CRP serum levels and Ordinal Scale for Clinical Improvement
Effect of the dose of corticosteroids on the nucleocapsid antigen serum levels
Correlation between the dose of corticosteroids and evolution of nucleocapsid serum levels
Effect of the remdesivir on the nucleocapsid antigen serum levels
Comparison of the nucleocapsid antigen serum levels between patients receiving and not receiving remdesivir
Effect of comorbidities on persistence of tracheal viral load assessed using tracheal aspirate semiquantitative PCR
Analysis of the effect of comorbidities on evolution of viral load assessed using tracheal aspirate semiquantitative PCR
Effect of age on persistence of tracheal viral load assessed using tracheal aspirate semiquantitative PCR
Analysis of the effect of age on evolution of viral load assessed using tracheal aspirate semiquantitative PCR
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