Early Detection & Intervention of Cerebral Palsy in Ireland

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 40
SponsorUniversity College Cork

About this trial

Cerebral palsy (CP) is the most common lifelong physical disability. It is defined as a non-progressive disorder of movement originating from neural lesions in the perinatal period, and is associated with a wide range of common comorbidities in many individuals. These include problems speaking, hearing, seeing, thinking, feeding and controlling their bladder. People with CP often have additional challenges such as behavioural and emotional issues, pain, and poor sleep. Many of these challenges respond well to intervention in early childhood, as brain plasticity is at its greatest in the first 2 years of life. However, in most clinical settings, the age for diagnosis of CP is between 24 to 29 months, after this window of neurodevelopmental opportunity.

This project will aim to improve the Early Detection of Cerebral Palsy in Ireland. This will be achieved by implementing an evidence-based approach to follow-up of High risk infants.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Legal guardians must be able and willing to give written informed consent and to comply with the requirements of this study protocol.

All preterm infants born ≤32 weeks Post Menstrual Age or ≤1500 gm birth weight

All encephalopathic infants

Neurological risk factors (e.g., injury/malformation on neuroimaging, persistently abnormal neurological exam)

Disqualifiers

Death prior to discharge from the neonatal unit.

Trial population

Newborns at high risk of developing CP will be identified and consented for inclusion prior to discharge from the Neonatal unit. Approximately 1500 infants will be recruited nationally over the study period from Cork University Maternity Hospital, University Maternity Hospital Limerick, The Coombe Hospital, The Rotunda Hospital and the National Maternity Hospital.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Reduce the age of CP diagnosis in Ireland.

Reduce the age of diagnosis of cerebral palsy in Ireland to less than 12 months of age by using evidence based standardised motor and neurological assessments at set time points.

Time frame
5 years
2

Standardised Approach to Assessing infant at risk of CP

To establish a standardised approach to assessing infants at risk of CP in High Risk Follow-up Clinics across Ireland.

Time frame
5 years

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University College Cork

Lead sponsor

National Maternity Hospital, Ireland

Collaborator

University Maternity Hospital Limerick

Collaborator

Cork University Maternity Hospital

Collaborator

Coombe Women and Infants University Hospital

Collaborator

The Rotunda Hospital

Collaborator

Cerebral Palsy Foundation

Collaborator