Early Identification of Cardivascular Damage Induced by Chemotherapy and Antineoplastic Treatments in Pediatric Age

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age0-18
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna

About this trial

To test whether the implementation of new diagnostic techniques (ultrasonography, speckle tracking, vascular stiffness study, cardiac MRI, and histologic studies) allows in CAYA (Childern, Adolescents, and Young Adults) cancer survivors a more sensitive and earlier identification of cardiovascular damage resulting from antineoplastic therapy that develops either acutely or remotely after completion of antineoplastic therapy.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of oncological pathology and need for antineoplastic treatment

Disqualifiers

None

Trial design

Design model

Single group

Treatments tested in this trial

  • Parameters of vascular stiffness

    Device

    VICORDER© is a noninvasive, quick and painless technique to be able to assess vascular elasticity and consists of placing a few sphygmomanometers (the same ones used to measure blood pressure) for a few minutes

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Incidence of cardiovascular events in CAYA cancer survivors during treatment and follow-up

Number of cardiovascular events, defined according to ESC 2022 guidelines (Eur Heart J. 2022;43:4229-4361), detected during treatment and follow-up. Time to occurrence of events will be measured relative to pre-treatment evaluation.

Time frame
From initiation of antineoplastic therapy up to 12 months post-therapy

Secondary outcomes

Other outcomes

Sponsors and contacts

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