Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.
men and women aged 18-35 years
member or beneficiary of a social security scheme,
for women, appropriate contraception will be mandatory, as well as a negative pregnancy test,
patients with a diagnosis of schizophrenia, schizoaffective disorder or schizophreniform disorder according to the DMS V
Female patients of childbearing period without effective contraception (oral, intramuscular hormonal, intrauterine device, or surgical);
Patients pregnant or nursing;
Presenting a serious somatic or neurological disease, especially Parkinson's disease, epilepsy, debilitating tardive dyskinesia, cardiovascular disease, severe liver or kidney;
Featuring against-indication for an MRI; including: metallic foreign body eye or intracranial, pacemaker, heart valve, surgical clips, claustrophobia, large tattoo in the upper part of the body, not compatible with 3T MRI
Patients suffering of schizophrenia will be included in this study. They do not have ever taken anti-psychotic treatment.
Case-only
Prospective
MRI
Procedure/SurgeryMagnetic Resonance Imagery will be performed on patients attempted by schizophrenia. The aim of this intervention is an early detection of the non-answering patients to the primary cares.
Score of the predictive value of the imagery markers.
To evaluate the predictive value of imaging markers (morphological and structural connectivity imaging) for the absence of remission at 3 months in patients with PEP.
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Centre Hospitalier Universitaire de Saint Etienne
Lead sponsor
Ministry of Health, France
Collaborator
