Early Neurological Outcome in Pediatric Encephalitis
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-12
SponsorAssiut University
About this trial
This prospective cohort study aims to identify baseline clinical, laboratory, and radiological factors at admission that are associated with early neurological outcomes in children with encephalitis admitted to Assiut University Children Hospital.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age from 1 month to 12 years
Possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition
Written informed consent from parents or legal guardians
Disqualifiers
Pre-existing severe neurodisability pediatric modified Rankin Scale greater than or equal to 3 before the index illness
Primary diagnosis of traumatic brain injury or cerebral malaria
Known inborn error of metabolism or neurodegenerative disorder prior to the encephalitis episode
Absence of documented neurologic outcome assessment
Trial population
Children aged 1 month to 12 years admitted to Assiut University Children Hospital with possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
88 Participants
are grouped into 1 trial groupGroup A: Single cohort: Children with encephalitis
Trial outcomes
Primary outcomes
1
Functional neurological outcome at discharge
Score on the pediatric modified Rankin Scale at hospital discharge. The scale ranges from 0 (no symptoms) to 6 (death), with higher scores indicating worse functional outcome
Time frame
Up to 30 daysSecondary outcomes
1
Duration of hospital stay
Length of hospital stay in days.
Time frame
Up to 30 days2
Need for intensive care unit admission
Number of children who require intensive care unit admission
Time frame
Up to 30 days3
Need for nasogastric tube feeding at discharge
Number of children who require nasogastric tube feeding at the time of hospital discharge
Time frame
Up to 30 days4
Nosocomial infections
Number of children who develop nosocomial infections during hospitalization
Time frame
Up to 30 daysLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: