Acute Effects of Estradiol Administration on Brain Function During Fear Learning
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexFemale
Age60+
SponsorUniversity of Arizona
About this trial
The goal of current study is to better understand how fear is processed in the brain and how these processes are influenced by cognition and hormones. This research will focus specifically on postmenopausal female adults, because age-related changes in cognition and declining estrogen levels may contribute to anxiety symptoms and PTSD risk later in life.
Eligibility criteria
Qualifiers
post-menopausal
normal or corrected-to-normal vision
English speaking
stable medication use (no changes in the past three months)
Disqualifiers
use of hormone therapy containing synthetic estrogen
MRI contraindications (e.g., irremovable ferrous metal in body, claustrophobia)
history of neurological disorder (including mild cognitive impairment) or moderate to severe traumatic brain injury
use of antipsychotic, opiate, or mood stabilizer (i.e., lithium) medication
Trial design
Treatments tested in this trial
- estradiol
Treatment groups
30 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov