The goal of this clinical trial is to develop a new cancer diagnostic and prognostic tool based on the dynamic and non-invasive detection of an exogenous volatile molecule, i.e., ethanol, from patients' samples.
Patients' blood plasma will be analyzed with a mixture of volatile organic compound-based probes, each targeting a specific glycosidase. The presence of a given glycosidase in a blood sample would thus be revealed by the detection of an ethanol isotope in the gas phase.
3 groups of patients with localized cancer (breast, prostate, pancreas) will be enrolled, as well as 1 group of patient without any cancer (control group).
For the patients, two 5ml plasma samples will be collected, one before and one after surgery for localized cancers. For healthy volunteers, only one 5ml plasma sample will be collected.
The primary objective will be to compare the levels of glycosidases measured in the blood of patients followed for localized cancer and referred for first surgery compared to control patients without cancer.
Group 1: 40 patients with definitively diagnosed, untreated, localized solid breast cancer referred for initial surgical treatment.
Refusal to participate in the research.
Patients benefiting from enhanced protection, namely: minors, pregnant/breastfeeding women, persons deprived of their liberty by a judicial or administrative decision, persons staying in a social care facility, adults under legal protection
Cancer patients undergoing oncological treatment.
Cancer not proven by anatomopathological examination.
Parallel
blood plasma sample
Biological/VaccineFor each patient, 5ml blood sample will be needed before the surgery and another 5ml blood sample one month after the surgery.
blood sampling
Biological/Vaccine5ml blood sample for control arm
To compare the levels of glycosidases measured in the blood samples of patients treated for a localized cancer (breast, lung or pancreatic cancer) compared to control patients without cancer.
Compare the seven glycosidase levels in patients with localized breast cancer versus cancer-free control patients.
Compare the seven glycosidase levels in patients with localized pancreatic cancer versus cancer-free control patients.
Compare the seven glycosidase levels in patients with localized lung cancer versus cancer-free control patients.
Compare the seven glycosidase levels according to cancer location (lung versus breast, pancreas versus breast, lung versus pancreas).
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